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3clpro activity  (TargetMol)


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    TargetMol 3clpro activity
    3clpro Activity, supplied by TargetMol, used in various techniques. Bioz Stars score: 91/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3clpro+activity/3CLpro-Targeted+Compound+Library/pm40634064-27-9-38
    Average 91 stars, based on 4 article reviews
    3clpro activity - by Bioz Stars, 2026-11
    91/100 stars

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    Activity Assay:

    Article Title: Identification of FDA-Approved Drugs That Inhibit SARS-CoV-2 and Human Norovirus Replication.
    Article Snippet: For the HuNoV experiment, 10% stool suspensions containing GII.4[GII.P16] HuNoV (EF23-1; GenBank Accession No. LC777250.1) were prepared, and virus titers were determined using the 50% tissue culture infectious dose (TCID50) assay in HIOs, as described previously.9) Compounds and Plasmids An FDA-approved drug library (1200 compounds; Catalog No. L4200, TargetMol, Boston, MA, U.S.A.) was used for compound screening. .. To test the effects of the hit compounds on 3CLpro activity and viral replication, we purchased auranofin (Catalog No. T1303), endoxifen (Catalog No. T4281), netupitant (Catalog No. T6905), pimozide (Catalog No. T2546), and regorafenib (Catalog No. T1792) from TargetMol. .. Cytotoxicity following compound treatment was measured using the Cytotoxicity Lactate Dehydrogenase (LDH) Assay Kit-WST (Dojindo, Kumamoto, Japan), as described previously.7) For the FlipGFP-3CLpro assay, we constructed mammalian expression vectors (pCAGGS) expressing FlipGFP containing the SARS-CoV-2 3CLpro cleavage site (VARLQSGFG).4) pcDNA3 H2B-mIFP T2A Mpro (wt), expressing wildtype SARS-CoV-2 3CLpro, was a gift from Xiaokun Shu (Addgene plasmid # 163079; http://n2t.net/addgene:163079; RRID:Addgene_163079).



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    Inhibitory activity of ACE2, BSS, and virus-derived 3CL protease enzymes by BB-PAC. A. ACE2 enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the ACE2 activity assay kit (BPS Bioscience). The right figure shows the results using the blueberry leaf fraction and the left figure shows the results using the blueberry stem fraction. B. TMPRSS2 enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the TMPRSS2 activity assay kit (BPS Bioscience). C. <t>3CLpro</t> enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the 3CLpro activity assay kit (BPS Bioscience).
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    Inhibitory activity of ACE2, BSS, and virus-derived 3CL protease enzymes by BB-PAC. A. ACE2 enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the ACE2 activity assay kit (BPS Bioscience). The right figure shows the results using the blueberry leaf fraction and the left figure shows the results using the blueberry stem fraction. B. TMPRSS2 enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the TMPRSS2 activity assay kit (BPS Bioscience). C. <t>3CLpro</t> enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the 3CLpro activity assay kit (BPS Bioscience).
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    Inhibitory activity of ACE2, BSS, and virus-derived 3CL protease enzymes by BB-PAC. A. ACE2 enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the ACE2 activity assay kit (BPS Bioscience). The right figure shows the results using the blueberry leaf fraction and the left figure shows the results using the blueberry stem fraction. B. TMPRSS2 enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the TMPRSS2 activity assay kit (BPS Bioscience). C. 3CLpro enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the 3CLpro activity assay kit (BPS Bioscience).

    Journal: Biochemical and Biophysical Research Communications

    Article Title: Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes

    doi: 10.1016/j.bbrc.2022.04.072

    Figure Lengend Snippet: Inhibitory activity of ACE2, BSS, and virus-derived 3CL protease enzymes by BB-PAC. A. ACE2 enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the ACE2 activity assay kit (BPS Bioscience). The right figure shows the results using the blueberry leaf fraction and the left figure shows the results using the blueberry stem fraction. B. TMPRSS2 enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the TMPRSS2 activity assay kit (BPS Bioscience). C. 3CLpro enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the 3CLpro activity assay kit (BPS Bioscience).

    Article Snippet: C. 3CLpro enzyme activity by BB-PAC fractions of Fr1(dotted line) as a control and Fr7 (solid line) at several different concentrations was measured by the 3CLpro activity assay kit (BPS Bioscience).

    Techniques: Activity Assay, Derivative Assay